Siglimet 50/500mg 10pcs - ePharma
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Generic Name: Sitagliptin 50mg + Metformin Hydrochloride 500mg

 Manufacturer/Distributor: Square Pharmaceuticals Ltd.


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Discount Price: ৳ 130.2
MRP: ৳ 140 7% Off

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✅ Description:

Indications

This can be shown as an aide to eat less and work out to make strides in glycemic control in grown-ups with sort 2 diabetes mellitus when treatment with both sitagliptin and metformin is fitting. Imperative confinements of use: This ought to not be utilized in patients with sort 1 diabetes or for the treatment of diabetic ketoacidosis, because it would not be effective in these settings. This has not been examined in patients with a history of pancreatitis. It is obscure whether patients with a history of pancreatitis are at expanded hazard for the improvement of pancreatitis when utilizing.

Pharmacology

This tablet combines two antihyperglycemic operators with complementary components of activity to move forward glycemic control in patients with sort 2 diabetes. Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and Metformin HCl, a part of the biguanide course. Sitagliptin may be a dipeptidyl peptidase-4 (DPP-4) inhibitor, which is accepted to apply its activities in patients with sort 2 diabetes by abating the inactivation of incretin hormones. Incretin hormones, counting glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are discharged by the digestive system all through the day, and levels are expanded in reaction to a feast. These hormones are quickly inactivated by the protein, DPP-4. The incretins are part of an endogenous framework included within the physiologic direction of glucose homeostasis. When blood glucose concentrations are ordinary or raised at that point GLP-1 and GIP increment affront union and discharge from pancreatic beta cells by intracellular signaling.

Dosage & Administration

Dose of film-coated tablet: The dosage of this tablet should be individualized on the basis of the patient's current regimen, effectiveness, and tolerability while not exceeding the maximum recommended daily dose of 100 mg sitagliptin and 2000 mg metformin. Initial combination therapy or maintenance of combination therapy should be individualized and left to the discretion of the health care provider.

This tablet should generally be given twice daily with meals, with gradual dose escalation, to reduce the gastrointestinal (GI) side effects due to metformin.

The starting dose of this tablet should be based on the patient’s current regimen. This tablet should be given twice daily with meals.

The recommended starting dose in patients not currently treated with metformin is 50 mg sitagliptin/500 mg metformin hydrochloride twice daily, with gradual dose escalation recommended to reduce gastrointestinal side effects associated with metformin.

The starting dose in patients already treated with metformin should provide sitagliptin dosed as 50 mg twice daily (100 mg total daily dose) and the dose of metformin already being taken. For patients taking metformin 850 mg twice daily, the recommended starting dose of this tablet is 50 mg sitagliptin/1000 mg metformin hydrochloride twice daily.

No studies have been performed specifically examining the safety and efficacy of Sitagliptin Phosphate Monohydrate INN/Metformin Hydrochloride BP in patients previously treated with other oral antihyperglycemic agents and switched to Sitagliptin Phosphate Monohydrate INN/Metformin Hydrochloride BP. Any change in therapy for type 2 diabetes should be undertaken with care and appropriate monitoring as changes in glycemic control can occur.

Dose of extended-release tablet: Administer once daily with a meal preferably in the evening. Gradually escalate the dose to reduce the gastrointestinal side effects due to Metformin. May adjust the dosing based on effectiveness and tolerability while not exceeding the maximum recommended daily dose of 100 mg Sitagliptin and 2000 mg Metformin extended-release. Maintain the same total daily dose of Sitagliptin and Metformin when changing between film-coated tablet and extended-release tablet, without exceeding the maximum recommended daily dose of 2000 mg Metformin extended-release.

Patients using two extended-release tablets (such as two 50/500 or two 50/1000 tablets) should take the two tablets together once daily. The 100 mg Sitagliptin/1000 mg Metformin HCI extended-release tablet should be taken as a single tablet once daily.

Patients treated with an insulin secretagogue or insulin: Co-administration of the combination with an insulin secretagogue (e.g., sulfonylurea) or insulin may require lower doses of the insulin secretagogue or insulin to reduce the risk of hypoglycemia.

Interaction

Cationic Drugs: Cationic drugs dispensed with renal tubular discharge: Utilize with caution. Phenprocoumon: Metformin may diminish the anticoagulant impact of phenprocoumon. Hence, near checking of the INR is recommended. Levothyroxine: Levothyroxine can decrease the hypoglycemic impact of metformin. Checking of blood glucose levels is prescribed, particularly when thyroid hormone treatment is started or ceased, and the dose of metformin must be balanced in case fundamental.

Contraindications

This tablet is contraindicated in patients with: Renal illness or renal brokenness, e.g., as recommended by serum creatinine levels ≥1.5 mg/dL [guys], ≥1.4 mg/dL [females] or unusual creatinine clearance which may moreover result in from conditions such as cardiovascular collapse (stun), intense myocardial dead tissue, and septicemia Acute or incessant metabolic acidosis, counting diabetic ketoacidosis, with or without coma. History of a genuine extreme touchiness response to this tablet or sitagliptin, such as anaphylaxis or angioedema. This tablet ought to be briefly ceased in patients experiencing radiologic thinks about including intravascular organization of iodinated differentiate materials, since the utilization of such items may result in intense modification of renal work.

Side Effects

The foremost common unfavorable responses detailed in ≥5% of patients at the same time beginning on sitagliptin and metformin and more commonly than in patients treated with fake treatment were the runs, upper respiratory tract disease, and headache. Adverse responses detailed in ≥5% of patients treated with sitagliptin in combination with sulfonylurea and metformin and more commonly than in patients treated with fake treatment in combination with sulfonylurea and metformin were hypoglycemia and headache. Hypoglycemia was the as it were antagonistic response detailed in ≥5% of patients treated with sitagliptin in combination with affront and metformin and more commonly than in patients treated with fake treatment in combination with affront and metformin.

Pregnancy & Lactation

Pregnancy Category B. There are no satisfactory and well-controlled things about pregnant ladies with Sitagliptin Phosphate Monohydrate INN/Metformin Hydrochloride BP or its personal components; subsequently, the security of Sitagliptin Phosphate Monohydrate INN/Metformin Hydrochloride BP in pregnant ladies isn't known. This tablet ought to be utilized amid pregnancy as it were in the event that clearly needed.

Precautions & Warnings

Lactic Acidosis- Lactic acidosis can happen due to metformin aggregation. The hazard increments with conditions such as sepsis, lack of hydration, the overabundance of liquor admissions, hepatic insufficiency, renal impedance, and intense congestive heart failure. Symptoms incorporate discomfort, myalgias, respiratory trouble, expanding drowsiness, and non-specific stomach trouble. Research facility variations from the norm incorporate moo pH, expanded anion hole, and lifted blood lactate. If acidosis is suspected, cease this tablet and hospitalize the understanding immediately. Regular observing of thyroid-stimulating hormone (TSH) levels is suggested in patients with hypothyroidism. Long-term treatment with metformin has been related to a diminished in vitamin B12 serum levels which may cause fringe neuropathy. Checking the vitamin B12 level is suggested.

Storage Conditions

Keep away from light and heat in a dry area. Keep out of children's reach.

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